In-situ preparation of poly(propylene fumarate) - hydroxyapatite composite

被引：55

作者：

Hakimimehr, D ^{[1
]}

Liu, DM ^{[1
]}

Troczynski, T ^{[1
]}

机构：

[1] Univ British Columbia, Dept Mat Engn, Vancouver, BC V6T 1Z4, Canada

来源：

BIOMATERIALS | 2005年 / 26卷 / 35期

关键词：

in-situ synthesis; amorphous calcium phosphate; poly(propylene fumarate); composite;

D O I：

10.1016/j.biomaterials.2005.05.065

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In-situ precipitation of hydroxyapatite (HAp) in the presence of poly(propylene fumarate) (PPF) is investigated. Amorphous calcium phosphate (ACP) precipitates in the presence of the polymer and remains in the amorphous form for a relatively long time, e.g. even after 24 h of coexistence with the mother solution. Our observations suggest that PPF interacts with the surface of the ACP particles and prevents them from transformation to crystalline hydroxyapatite. The PPF polymer seems to be more efficient in hindering the ACP to HAp transformation at higher pH conditions. From spectroscopic observations we hypothesize that the C=O bond of the PPF molecules interact with the calcium ion of the ACP particles. In case of low molecular weight PPF this interaction may lead to the incorporation of the polymer within the growing ACP particles. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：7297 / 7303

页数：7

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