Prolonged Selection of pfmdr1 Polymorphisms After Treatment of Falciparum Malaria With Artemether-Lumefantrine in Uganda

被引：69

作者：

Baliraine, Frederick N. ^{[1
]}

Rosenthal, Philip J. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷 / 07期

基金：

美国国家卫生研究院;

关键词：

PLASMODIUM-FALCIPARUM; INCREASED SENSITIVITY; ANTIMALARIAL-DRUGS; RESISTANCE; CHILDREN; ALLELES; GENE; ARTEMISININ; MEFLOQUINE; THERAPY;

D O I：

10.1093/infdis/jir486

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We compared the prevalence of key pfmdr1 alleles between pretreatment Plasmodium falciparum parasite isolates and parasites that emerged after treatment of uncomplicated malaria in a longitudinal cohort of Ugandan children. The pfmdr1 86N, 184F, and 1246D alleles were selected after treatment with artemether-lumefantrine, but not after artesunate-amodiaquine or amodiaquine-sulfadoxine-pyrimethamine. Remarkably, selection persisted in infections presenting up to about 60 days after treatment with artemether-lumefantrine. Thus, parasites selected for decreased drug sensitivity can appear long after predicted exposure to antimalarial drugs. Continued surveillance of the clinical efficacy and in vitro activity of new combination therapies is warranted.

引用

页码：1120 / 1124

页数：5

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