Flurbiprofen-loaded nanospheres:: analysis of the matrix structure by thermal methods

被引：39

作者：

Gamisans, F

Lacoulonche, F

Chauvet, A

Espina, M

García, ML

Egea, MA

机构：

[1] Univ Barcelona, Fac Pharm, Dept Pharm, Physicochem Unit, E-08028 Barcelona, Spain

[2] Fac Pharm Montpellier, Lab Chim Gen & Minerale, F-34060 Montpellier 2, France

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 179卷 / 01期

关键词：

ocular drug delivery; nanospheres; poly-epsilon-caprolactone; thermal methods;

D O I：

10.1016/S0378-5173(98)00381-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We report the preparation and evaluation of flurbiprofen loaded-poly-epsilon-caprolactone nanospheres obtained by solvent displacement method. Characterization by thermal methods, infrared spectroscopy and X-ray diffraction analysis can reveal the dispersion state of the drug inside the nanospheres. Such information predicts the stability of the particles and the drug release behaviour. The study has indicated the presence of a molecular dispersed system. In addition, construction of a phase diagram has allowed us to determine the drug/polymer ratios at which flurbiprofen has the highest entrapment efficiency. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：37 / 48

页数：12

共 18 条

[1] DETERMINATION OF IBUPROFEN IN CAPILLARY AND VENOUS PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ULTRAVIOLET DETECTION [J].