Selective cell adhesion on femtosecond laser-microstructured polydimethylsiloxane

被引：15

作者：

Alshehri, A. M. ^{[1
,2
]}

Hadjiantoniou, S. ^{[1
]}

Hickey, R. J. ^{[1
]}

Al-Rekabi, Z. ^{[3
]}

Harden, J. L. ^{[1
]}

Pelling, A. E. ^{[1
]}

Bhardwaj, V. R. ^{[1
]}

机构：

[1] Univ Ottawa, Dept Phys, 150 Louis Pasteur, Ottawa, ON K1N 6N5, Canada

[2] King Khalid Univ, Dept Phys, POB 9004, Abha, Saudi Arabia

[3] Univ Washington, Dept Mech Engn, Seattle, WA USA

来源：

BIOMEDICAL MATERIALS | 2016年 / 11卷 / 01期

关键词：

selective cell adhesion; patterned cell growth; surface microstructuring; femtosecond laser materials processing; FABRICATED SPIKE STRUCTURES; SELF-ASSEMBLED MONOLAYERS; OSTEOBLAST-LIKE CELLS; SUPERHYDROPHOBIC SURFACES; INDUCED BREAKDOWN; CONTACT GUIDANCE; TUNABLE ADHESION; PULSES; PDMS; ATTACHMENT;

D O I：

10.1088/1748-6041/11/1/015014

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

We show that femtosecond laser irradiation of polydimethylsiloxane ( PDMS) enables selective and patterned cell growth by altering the wetting properties of the surface associated with chemical and/or topographical changes. In the low pulse energy regime, the surface becomes less hydrophobic and exhibits a low water contact angle compared to the pristine material. X-ray photoelectron spectroscopy (XPS) also reveals an increased oxygen content in the irradiated regions, to which the C2C12 cells and rabbit anti-mouse protein were found to attach preferentially. In the high pulse energy regime, the laser-modified regions exhibit superhydrophobicity and were found to inhibit cell adhesion, whereas cells were found to attach to the surrounding regions due to the presence of nanoscale debris generated by the ablation process.

引用

页数：9

共 64 条

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