共 51 条
[51]
YAMANE A, 1994, ONCOGENE, V9, P2683
Liver Sinusoidal Endothelial Cells in Hepatic Fibrosis
被引：478
作者：
DeLeve, Laurie D.
[1
,2
]
机构：
[1] USC, Keck Med, Div Gastrointestinal & Liver Dis, Los Angeles, CA 90033 USA
[2] USC, Keck Med, USC Res Ctr Liver Dis, Los Angeles, CA 90033 USA
来源：
关键词：
RECEPTOR-MEDIATED ENDOCYTOSIS;
LOW-DENSITY-LIPOPROTEIN;
TREATED SERUM-ALBUMIN;
NITRIC-OXIDE SYNTHASE;
RAT-LIVER;
HYALURONAN RECEPTOR;
EXPERIMENTAL CIRRHOSIS;
SCAVENGER RECEPTORS;
STELLATE CELLS;
GROWTH-FACTOR;
D O I：
10.1002/hep.27376
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
100201 [内科学];
摘要：
Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of an organized basement membrane not only precedes fibrosis, but is also permissive for hepatic stellate cell activation and fibrosis. Thus, dysregulation of the LSEC phenotype is a critical step in the fibrotic process. Both a vascular endothelial growth factor (VEGF)-stimulated, nitric oxide (NO)-independent pathway and a VEGF-stimulated NO-dependent pathway are necessary to maintain the differentiated LSEC phenotype. The NO-dependent pathway is impaired in capillarization and activation of this pathway downstream from NO restores LSEC differentiation in vivo. Restoration of LSEC differentiation in vivo promotes HSC quiescence, enhances regression of fibrosis, and prevents progression of cirrhosis. (Hepatology 2015;61:1740-1746)
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页码：1740 / 1746
页数：7
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