Magnetic particle diverter in an integrated microfluidic format

被引:53
作者
Pekas, N
Granger, M
Tondra, M
Popple, A
Porter, MD
机构
[1] Iowa State Univ, Dept Chem, Inst Combinatorial Discovery, Ames, IA 50010 USA
[2] Iowa State Univ, Dept Chem Engn, Ames, IA 50010 USA
[3] Iowa State Univ, USDOE, Ames Lab, Ames, IA 50010 USA
[4] NVE Corp, Eden Prairie, MN 55344 USA
关键词
micromagnetic system; microfluidics; lab-on-a-chip; diverter; flow; Y-shaped junction; magnetic separation;
D O I
10.1016/j.jmmm.2005.01.077
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
A fully integrated micromagnetic particle diverter and microfluidic system are described. Particles are diverted via an external uniform magnetic field perturbed at the microscale by underlying current straps. The resulting magnetic force deflects particles across a flow stream into one of the two channels at a Y-shaped junction. The basic theoretical framework, design, and operational demonstration of the device are presented. (c) 2005 Published by Elsevier B.V.
引用
收藏
页码:584 / 588
页数:5
相关论文
共 14 条
[1]  
[Anonymous], 1994, CRC HDB CHEM PHYS
[2]   Development and Characterization of Microfluidic Devices and Systems for Magnetic Bead-Based Biochemical Detection [J].
Choi, Jin-Woo ;
Oh, Kwang W. ;
Han, Arum ;
Okulan, Nihat ;
Wijayawardhana, C. Ajith ;
Lannes, Chad ;
Bhansali, Shekhar ;
Schlueter, Kevin T. ;
Heineman, William R. ;
Halsall, H. Brain ;
Nevin, Joseph H. ;
Helmicki, Arthur J. ;
Henderson, H. Thurman ;
Ahn, Chong H. .
BIOMEDICAL MICRODEVICES, 2001, 3 (03) :191-200
[3]   Manipulation of magnetic microbeads in suspension using micromagnetic systems fabricated with soft lithography [J].
Deng, T ;
Whitesides, GM ;
Radhakrishnan, M ;
Zabow, G ;
Prentiss, M .
APPLIED PHYSICS LETTERS, 2001, 78 (12) :1775-1777
[4]   Using magnetic beads to isolate inside-out glut1-containing vesicles from 3T3-L1 adipocyte plasma membranes [J].
Fisher, MD ;
Frost, SC .
ANALYTICAL BIOCHEMISTRY, 1997, 251 (01) :125-126
[5]  
Gerber R. B. R. R., 1983, HIGH GRADIENT MAGNET
[6]   Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: Biotechnological applications [J].
Graham, DL ;
Ferreira, H ;
Bernardo, J ;
Freitas, PP ;
Cabral, JMS .
JOURNAL OF APPLIED PHYSICS, 2002, 91 (10) :7786-7788
[7]   Magnetic design considerations for devices and particles used for biological high-gradient magnetic separation (HGMS) systems [J].
Hatch, GP ;
Stelter, RE .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) :262-276
[8]  
KANTOR AB, 1998, CELL SEPARATION METH
[9]   Microelectromagnets for the control of magnetic nanoparticles [J].
Lee, CS ;
Lee, H ;
Westervelt, RM .
APPLIED PHYSICS LETTERS, 2001, 79 (20) :3308-3310
[10]   Detection and characterization of carcinoma cells in the blood [J].
Racila, E ;
Euhus, D ;
Weiss, AJ ;
Rao, C ;
McConnell, J ;
Terstappen, LWMM ;
Uhr, JW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) :4589-4594