Systemic inflammation and fracture healing

被引：196

作者：

Bastian, Okan ^{[1
]}

Pillay, Janesh ^{[2
]}

Alblas, Jacqueline ^{[3
]}

Leenen, Luke ^{[1
]}

Koenderman, Leo ^{[2
]}

Blokhuis, Taco ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Surg, NL-3508 GA Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Pulm Dis, NL-3508 GA Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Dept Orthoped, NL-3508 GA Utrecht, Netherlands

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2011年 / 89卷 / 05期

关键词：

leukocytosis; neutrophil; priming; bone; repair; DELTA-T-CELLS; RESPONSE SYNDROME; SKELETAL DEVELOPMENT; MOLECULAR ASPECTS; TRAUMA PATIENTS; BETA-GLUCAN; IN-VIVO; NEUTROPHIL; ANGIOGENESIS; HEMATOMA;

D O I：

10.1189/jlb.0810446

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Apart from their pivotal role in the host defense against pathogens, leukocytes are also essential for bone repair, as fracture healing is initiated and directed by a physiological inflammatory response. Leukocytes infiltrate the fracture hematoma and produce several growth and differentiation factors that regulate essential downstream processes of fracture healing. Systemic inflammation alters the numbers and properties of circulating leukocytes, and we hypothesize that these changes are maintained in tissue leukocytes and will lead to impairment of fracture healing after major trauma. The underlying mechanisms will be discussed in this review. J. Leukoc. Biol. 89: 669-673; 2011.

引用

页码：669 / 673

页数：5

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