Correlation of cortisol in 1-cm hair segment with salivary cortisol in human: hair cortisol as an endogenous biomarker

被引:87
作者
Xie, Qiaozhen [1 ]
Gao, Wei [1 ]
Li, Jifeng [1 ]
Qiao, Ting [1 ]
Jin, Jing [1 ]
Deng, Huihua [1 ]
Lu, Zuhong [1 ]
机构
[1] Southeast Univ, Res Ctr Learning Sci, Minist Educ, Key Lab Child Dev & Learning Sci, Nanjing 210096, Jiangsu, Peoples R China
关键词
cortisol; endogenous; hair; saliva; tandem mass spectrometry; STRESS; DRUG; ART;
D O I
10.1515/CCLM.2011.706
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
100118 [医学信息学]; 100208 [临床检验诊断学];
摘要
Background: Cortisol level in human hair would be an endogenous biomarker for the retrospective assessment of long-term central hypothalamo-pituitary-adrenal activity. However, no direct evidence supports that blood-related diffusion is a biologically endogenous source of hair cortisol in humans. The present study aims to validate the direct correlation between cortisol in 1-cm hair segments and salivary cortisol in healthy humans. Methods: We collected three saliva samples from the same participant at Time 1, Time 2 (1 week later) and Time 3 (2 weeks later), and hair 4 weeks later. Cortisol levels in I-cm hair segments and saliva were determined with high performance liquid chromatography tandem mass spectrometry Results: Salivary cortisol at Time I was significantly associated with that at Time 2 (r =0.514, p = 0.003), but not with that at Time 3 (r = 0.187, p = 0.305); and the one at Time 2 was significantly associated with that at Time 3 (r = 0.380, p = 0.032). Hair cortisol was significantly correlated with salivary cortisol at Time 2 (r = 0.389, p < 0.05) and average salivary cortisol (r = 0.383, p < 0.05) from three sampling. Conclusions: Our results confirmed that blood-related diffusion mechanism is a biologically endogenous source of hair cortisol.
引用
收藏
页码:2013 / 2019
页数:7
相关论文
共 21 条
[1]
Neuroimmunology of stress: Skin takes center stage [J].
Arck, Petra C. ;
Slominski, Andrzej ;
Theoharides, Theoharis C. ;
Peters, Eva M. J. ;
Paus, Ralf .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (08) :1697-1704
[2]
Mechanisms of drug incorporation into hair [J].
Cone, EJ .
THERAPEUTIC DRUG MONITORING, 1996, 18 (04) :438-443
[3]
Analysis of endogenous cortisol concentrations in the hair of rhesus macaques [J].
Davenport, Matthew D. ;
Tiefenbacher, Stefan ;
Lutz, Corrine K. ;
Novak, Melinda A. ;
Meyer, Jerrold S. .
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2006, 147 (03) :255-261
[4]
Higher cortisol content in hair among long-term unemployed individuals compared to controls [J].
Dettenborn, L. ;
Tietze, A. ;
Bruckner, F. ;
Kirschbaum, C. .
PSYCHONEUROENDOCRINOLOGY, 2010, 35 (09) :1404-1409
[5]
Acute stressors and cortisol responses: A theoretical integration and synthesis of laboratory research [J].
Dickerson, SS ;
Kemeny, ME .
PSYCHOLOGICAL BULLETIN, 2004, 130 (03) :355-391
[6]
HPLC-FLU detection of cortisol distribution in human hair [J].
Gao, Wei ;
Xie, Qiaozhen ;
Jin, Jing ;
Qiao, Ting ;
Wang, Haiyang ;
Chen, Liqin ;
Deng, Huihua ;
Lu, Zuhong .
CLINICAL BIOCHEMISTRY, 2010, 43 (7-8) :677-682
[7]
Effects of shampoo and water washing on hair cortisol concentrations [J].
Hamel, Amanda F. ;
Meyer, Jerrold S. ;
Henchey, Elizabeth ;
Dettmer, Amanda M. ;
Suomi, Stephen J. ;
Novak, Melinda A. .
CLINICA CHIMICA ACTA, 2011, 412 (3-4) :382-385
[8]
Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal (HPA) axis and synthesize cortisol [J].
Ito, N ;
Ito, T ;
Kromminga, A ;
Bettermann, A ;
Takigawa, M ;
Kees, F ;
Straub, RH ;
Paus, R .
FASEB JOURNAL, 2005, 19 (08) :1332-+
[9]
The relationship between stress and hair cortisol in healthy pregnant women [J].
Kalra, Sanjog ;
Einarson, Adrienne ;
Karaskov, Tatyana ;
Van Uum, Stan ;
Koren, Gideon .
CLINICAL AND INVESTIGATIVE MEDICINE, 2007, 30 (02) :E103-E107
[10]
Hair as a retrospective calendar of cortisol production-Increased cortisol incorporation into hair in the third trimester of pregnancy [J].
Kirschbaum, Clemens ;
Tietze, Antje ;
Skoluda, Nadine ;
Dettenborn, Lucia .
PSYCHONEUROENDOCRINOLOGY, 2009, 34 (01) :32-37