Reparative osteogenesis during transplantation of mesenchymal stem cells

被引:7
作者
Fatkhudinov, TK [1 ]
Gol'dshtein, DV
Pulin, AA
Shamenkov, DA
Rzhaninova, AA
Gornostaeva, SA
Grigor'yan, AS
Kulakov, AA
机构
[1] Russian Acad Med Sci, Inst Stem Cell & Cell Technol, Moscow, Russia
[2] Russian Minist Hlth & Social Dev, Cent Res Inst Stomatol, Moscow, Russia
[3] ReMeTeks Closed Co, Moscow, Russia
关键词
reparative osteogenesis; mesenchymal stem cell; histomorphometric study;
D O I
10.1007/s10517-005-0421-0
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Reparative osteogenesis was studied after xenotransplantation of suspension cell graft from human mesenchymal stem cells. A model of experimental damage to rat femoral diaphysis was developed. The state of animals was satisfactory and non-depressed in the early and late postoperation period. We revealed no local pathological reactions and complications. Administration of mesenchymal stem cells into the area of bone defect accelerated and improved regeneration. Unilateral transplantation of the cell graft stimulated regeneration in the contralateral limb due to acceleration of bone tissue maturation. On day 90 after treatment the bone regenerate was completely developed in the area of defect in animals of various groups. The newly formed bone tissue was well integrated into the bone organ.
引用
收藏
页码:96 / 99
页数:4
相关论文
共 6 条
[1]  
DULAEV AK, 2003, MED AKAD Z, V3, P59
[2]  
FATKHUDINOV TK, 2003, B EKSP BIOL MED, P44
[3]   BONE-MARROW OSTEOGENIC STEM-CELLS - INVITRO CULTIVATION AND TRANSPLANTATION IN DIFFUSION-CHAMBERS [J].
FRIEDENSTEIN, AJ ;
CHAILAKHYAN, RK ;
GERASIMOV, UV .
CELL AND TISSUE KINETICS, 1987, 20 (03) :263-272
[4]   Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue [J].
Lee, RH ;
Kim, B ;
Choi, I ;
Kim, H ;
Choi, HS ;
Suh, K ;
Bae, YC ;
Jung, JS .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2004, 14 (4-6) :311-324
[5]   Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells [J].
Qi, HL ;
Aguiar, DJ ;
Williams, SM ;
La Pean, A ;
Pan, W ;
Verfaillie, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (06) :3305-3310
[6]  
RZHANINOVA AA, 2005, KLET TECKHNOL BIOL M, P34