Oleanene triterpenes from Sedum lineare Thunb

One new olean-13(18)-ene-3,12,19-trione (1), and two known oleanene triterpenes delta-amyrone (2), and delta-amyrine acetate (3) were isolated from the petroleum ether fraction from an alcoholic extract of the whole plant of Sedum linear Thunb. The new compound was characterized by means of spectroscopic methods including 1D, 2D NMR and HR-ESI-MS, and was further confirmed by X-ray diffraction analysis. The known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature. In addition, the inhibitory effects of the compounds isolated on the TNF-alpha and NO production were examined in vitro. (C) 2011 Elsevier B.V. All rights reserved.