A different TIPE of immune homeostasis

被引：198

作者：

Freundt, Eric C. ^{[1
]}

Bidere, Nicolas ^{[2
]}

Lenardo, Michael J. ^{[1
]}

机构：

[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Paris 11, Hop Paul Brousse, INSERM, Unite 542, F-94804 Villejuif, France

来源：

CELL | 2008年 / 133卷 / 03期

关键词：

D O I：

10.1016/j.cell.2008.04.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Proteins with death effector domains (DED) are key signal transducers involved in cell death and inflammation. In this issue of Cell, Sun et al. (2008) describe TIPE2, a DED protein that negatively regulates both T cell receptor and Toll-like receptor signaling. These findings reveal a new element critical to the maintenance of homeostasis in both the adaptive and innate immune systems.

引用

收藏

页码：401 / 402

页数：2

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