Understanding transgenerational epigenetic inheritance via the gametes in mammals

被引：522

作者：

Daxinger, Lucia ^{[1
]}

Whitelaw, Emma ^{[1
]}

机构：

[1] Queensland Inst Med Res, Herston, Qld 4006, Australia

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 03期

基金：

英国医学研究理事会;

关键词：

HERITABLE GERMLINE EPIMUTATION; ORIGIN ALLELIC EXPRESSION; DNA METHYLATION; GENE-EXPRESSION; TRANSPOSABLE ELEMENTS; METASTABLE EPIALLELES; HISTONE MODIFICATIONS; HYBRID DYSGENESIS; MONOZYGOTIC TWIN; COMPLEX PATTERNS;

D O I：

10.1038/nrg3188

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

It is known that information that is not contained in the DNA sequence-epigenetic information-can be inherited from the parent to the offspring. However, many questions remain unanswered regarding the extent and mechanisms of such inheritance. In this Review, we consider the evidence for transgenerational epigenetic inheritance via the gametes, including cases of environmentally induced epigenetic changes. The molecular basis of this inheritance remains unclear, but recent evidence points towards diffusible factors, in particular RNA, rather than DNA methylation or chromatin. Interestingly, many cases of epigenetic inheritance seem to involve repeat sequences.

引用

页码：153 / 162

页数：10

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