Pathologic subgroups of nonspecific interstitial pneumonia -: Differential diagnosis from other idiopathic interstitial pneumonias on high-resolution computed tomography

被引:31
作者
Tsubamoto, M
Müller, NL
Johkoh, T
Ichikado, K
Taniguchi, H
Kondoh, Y
Fujimoto, K
Arakawa, H
Koyama, M
Kozuka, T
Inoue, A
Sumikawa, M
Murai, S
Honda, O
Tomiyama, N
Hamada, S
Nakamura, H
机构
[1] Osaka Univ, Grad Sch Med, Dept Radiol, Suita, Osaka 5650825, Japan
[2] Univ British Columbia, Dept Radiol, Vancouver, BC V5Z 1M9, Canada
[3] Vancouver Hosp & Hlth Sci Ctr, Vancouver, BC V5Z 1M9, Canada
[4] Osaka Univ, Grad Sch Med, Dept Med Phys, Osaka, Japan
[5] Kumamoto Univ, Sch Med, Dept Internal Med 1, Kumamoto 860, Japan
[6] Tosei Gen Hosp, Dept Resp Med, Aichi, Japan
[7] Kurume Univ, Sch Med, Dept Radiol, Fukuoka, Japan
关键词
interstitial pneumonia; nonspecific interstitial pneumonia; high-resolution computed tomography;
D O I
10.1097/01.rct.0000182853.90520.84
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: To detennine whether the subtypes of nonspecific interstitial pneumonia (NSIP) could be differentiated from other idiopathic interstitial pneumonias (IIPs) on the basis of findings on high-resolution computed tomography (CT). Methods: Two observers evaluated the high-resolution CT findings in 90 patients with IIPs. The patients included 36 with NSIP, I I with usual interstitial pneumonia (UIP), 8 with cryptogenic organizing pneumonia (COP), 10 with acute interstitial pneumonia (AIP), 14 with desquamative interstitial pneumonia (DIP) or respiratory bronchiolitis-associated interstitial lung disease (RB-ILD), and I I with lymphoid interstitial pneumonia (LIP). The NSIP cases were subdivided into group 1 NSIP (n = 6), group 2 NSIP (n = 15), and group 3 NSIP (n = 15). Results: Observers made a correct diagnosis with a high level of confidence in 65% of NSIP cases, 91% of UIP cases, 44% of COP cases, 40% of AIP cases, 32% of DIP or RB-ILD cases, and 82% of LIP cases. Group 1 NSIP was misdiagnosed as AIP, DIP or RB-ILD, and LIP in 8.3% of patients respectively. Group 2 NSIP was misdiagnosed as COP in 10% of patients, LIP in 6.7%, AIP in 3.3%, and DIP or RB-ILD in 3.3%. Group 3 NSIP was misdiagnosed as UIP in 6.7% of patients, COP in 6.7%, and DIP or RB-ILD in 3.3%. Conclusions: In most patients, NSIP can be distinguished front other IIPs based on the findings on high-resolution CT. Only a small percentage of patients with predominantly fibrotic NSIP (group 3 NSIP) show overlap with the high-resolution CT findings of UIP.
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页码:793 / 800
页数:8
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