Diffusion-weighted imaging of the spinal cord and optic nerve

The optic nerve and spinal cord are technically challenging to investigate with any magnetic resonance imaging (MRI) technique due to the effect of the surrounding cerebrospinal fluid and lipid, and the presence of nearby bony structures. Motion and the relatively small cross-section of the structures make diffusion-weighted imaging even harder. With cartful choice of pulse sequence and parameters, however, apparent diffusion coefficient (ADC) measurements are now possible in the optic nerve, and both ADC and diffusion tenser imaging (DTI) measurements are becoming available in the spinal cord. (C) 2001 Elsevier Science B.V. All rights reserved.