Divide and conquer: Division of labor by B-1B cells

被引:50
作者
Alugupalli, KR [1 ]
Gerstein, RM [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Worcester, MA 01605 USA
关键词
D O I
10.1016/j.immuni.2005.07.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Capsular polysaccharides enhance bacterial virulence. In this issue of Immunity, Haas et al. (2005) demonstrate a division of labor between the B-1 B cell subsets: natural antibodies from B-1a cells limit infection by Streptococcus pneumoniae, whereas B-1b cells generate the anticapsule-induced response that prevents fatal infection.
引用
收藏
页码:1 / 2
页数:2
相关论文
共 11 条
  • [1] B1b lymphocytes confer T cell-independent long-lasting immunity
    Alugupalli, KR
    Leong, JM
    Woodland, RT
    Muramatsu, M
    Honjo, T
    Gerstein, RM
    [J]. IMMUNITY, 2004, 21 (03) : 379 - 390
  • [2] Blood dendritic cells interact with splenic marginal zone B cells to initiate T-Independent immune responses
    Balázs, M
    Martin, F
    Zhou, T
    Kearney, JF
    [J]. IMMUNITY, 2002, 17 (03) : 341 - 352
  • [3] Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion
    Baumgarth, N
    Tung, JW
    Herzenberg, LA
    [J]. SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 2005, 26 (04): : 347 - 362
  • [4] The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency
    Carsetti, R
    Rosado, MM
    Donnanno, S
    Guazzi, V
    Soresina, A
    Meini, M
    Plebani, A
    Aiuti, F
    Quinti, I
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 115 (02) : 412 - 417
  • [5] B cell development pathways
    Hardy, RR
    Hayakawa, K
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 : 595 - 621
  • [6] Kantor AB, 1997, J IMMUNOL, V158, P1175
  • [7] IL-9-induced expansion of B-1b cells restores numbers but not function of B-1 lymphocytes in xid mice
    Knoops, L
    Louahed, J
    Renauld, JC
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (10) : 6101 - 6106
  • [8] B1 cells: similarities and differences with other B cell subsets
    Martin, F
    Kearney, JF
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (02) : 195 - 201
  • [9] What can children gain from pneumococcal conjugate vaccines?
    Peltola, H
    Booy, R
    Schmitt, HJ
    [J]. EUROPEAN JOURNAL OF PEDIATRICS, 2004, 163 (09) : 509 - 516
  • [10] Vos Q, 2000, IMMUNOL REV, V176, P154