Biochemical mass spectrometry: Worth the weight?

被引：22

作者：

Fitzgerald, MC

Siuzdak, G

机构：

[1] Department of Chemistry, Scripps Research Institute, BCC-157, San Diego, CA 92037

来源：

CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 09期

关键词：

D O I：

10.1016/S1074-5521(96)90245-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The utility of mass spectrometry for the analysis of biological molecules has been enhanced by the development of two techniques that generate gas-phase ions via nondestructive vaporization and ionization. These techniques can be used not only to determine the primary structure of biological molecules with unprecedented accuracy, but also to map noncovalent biomolecular interactions.

引用

收藏

页码：707 / 715

页数：9

相关论文

共 49 条

[1]

ARNOTT D, 1993, CLIN CHEM, V39, P2005

[2] DIRECT OBSERVATION OF A TERNARY COMPLEX BETWEEN THE DIMERIC ENZYME HIV-1 PROTEASE AND A SUBSTRATE-BASED INHIBITOR [J].

BACA, M ;

KENT, SBH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (10) :3992-3993

[3] ANTISENSE DNA OLIGONUCLEOTIDES .1. THE USE OF IONSPRAY TANDEM MASS-SPECTROMETRY FOR THE SEQUENCE VERIFICATION OF METHYLPHOSPHONATE OLIGODEOXYRIBONUCLEOTIDES [J].

BAKER, TR ;

KEOUGH, T ;

DOBSON, RLM ;

RILEY, TA ;

HASSELFIELD, JA ;

HESSELBERTH, PE .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1993, 7 (03) :190-194

[4]

Burlingame AL, 1996, ANAL CHEM, V68, pR599, DOI 10.1021/a1960021u

[5] WEIGHING NAKED PROTEINS - PRACTICAL, HIGH-ACCURACY MASS MEASUREMENT OF PEPTIDES AND PROTEINS [J].

CHAIT, BT ;

KENT, SBH .

SCIENCE, 1992, 257 (5078) :1885-1894

[6]

CHENG X, 1996, J CHEM SOC CHEM COMM, V6, P747

[7] Direct measurement of oligonucleotide binding stoichiometry of gene V protein by mass spectrometry [J].

Cheng, XH ;

Harms, AC ;

Goudreau, PN ;

Terwilliger, TC ;

Smith, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (14) :7022-7027

[8] PROBING THE SOLUTION STRUCTURE OF THE DNA-BINDING PROTEIN MAX BY A COMBINATION OF PROTEOLYSIS AND MASS-SPECTROMETRY [J].

COHEN, SL ;

FERREDAMARE, AR ;

BURLEY, SK ;

CHAIT, BT .

PROTEIN SCIENCE, 1995, 4 (06) :1088-1099

[9] RAPID TRYPTIC MAPPING USING ENZYMATICALLY ACTIVE MASS-SPECTROMETER PROBE TIPS [J].

DOGRUEL, D ;

WILLIAMS, P ;

NELSON, RW .

ANALYTICAL CHEMISTRY, 1995, 67 (23) :4343-4348

[10] MASS DISCRIMINATION IN MATRIX-ASSISTED LASER-DESORPTION IONIZATION TIME-OF-FLIGHT MASS-SPECTROMETRY - A STUDY USING CROSS-LINKED OLIGOMERIC COMPLEXES [J].

FARMER, TB ;

CAPRIOLI, RM .

JOURNAL OF MASS SPECTROMETRY, 1995, 30 (09) :1245-1254

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