Whole hemisphere autoradiography of the postmortem human brain

被引：64

作者：

Hall, H ^{[1
]}

Halldin, C ^{[1
]}

Farde, L ^{[1
]}

Sedvall, G ^{[1
]}

机构：

[1] Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, Karolinska Inst, S-17176 Stockholm, Sweden

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1998年 / 25卷 / 08期

关键词：

autoradiography; human brain; dopamine receptors; serotonin receptors; postmortem;

D O I：

10.1016/S0969-8051(98)00053-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Whole hemisphere autoradiography (WHA) with selective high-affinity radioligands is a new tool in studying the distribution of receptors and of other neuronal components postmortem in brains from controls vs. subjects with psychiatric and neurologic diseases. WHA can be performed with several different isotopes (e.g., H-3, I-125 and C-11), and is in addition to characterization studies also used as a tool in early radioligand development. Moreover, using this technique, high-resolution images are obtained that are complementary to those obtained in vivo with e.g., PET and SPECT. Results on dopamine and serotonin receptor subtypes as well as of their transporters show that WHA is a very suitable technique for the detailed characterization of the distribution in the whole human brain. NUCL MED BIOL 25;8:715-119, 1998. (C) 1998 Elsevier Science Inc.

引用

页码：715 / 719

页数：5

共 38 条

[11]

Hall H, 1996, SYNAPSE, V23, P115, DOI 10.1002/(SICI)1098-2396(199606)23:2<115::AID-SYN7>3.0.CO

[12]

2-C

[13] DISTRIBUTION OF D-1-DOPAMINE AND D-2-DOPAMINE RECEPTORS, AND DOPAMINE AND ITS METABOLITES IN THE HUMAN BRAIN [J].

HALL, H ;

SEDVALL, G ;

MAGNUSSON, O ;

KOPP, J ;

HALLDIN, C ;

FARDE, L .

NEUROPSYCHOPHARMACOLOGY, 1994, 11 (04) :245-256

[14] Autoradiographic localisation of D-3-dopamine receptors in the human brain using the selective D-3-dopamine receptor agonist (+)-[H-3]PD 128907 [J].

Hall, H ;

Halldin, C ;

Dijkstra, D ;

Wikstrom, H ;

Wise, LD ;

Pugsley, TA ;

Sokoloff, P ;

Pauli, S ;

Farde, L ;

Sedvall, G .

PSYCHOPHARMACOLOGY, 1996, 128 (03) :240-247

[15] HUMAN DOPAMINE RECEPTOR SUBTYPES - INVITRO BINDING ANALYSIS USING H-3 SCH 23390 AND H-3 RACLOPRIDE [J].

HALL, H ;

FARDE, L ;

SEDVALL, G .

JOURNAL OF NEURAL TRANSMISSION, 1988, 73 (01) :7-21

[16] NCQ 298, A NEW SELECTIVE IODINATED SALICYLAMIDE LIGAND FOR THE LABELING OF DOPAMINE-D2 RECEPTORS [J].

HALL, H ;

HOGBERG, T ;

HALLDIN, C ;

KOHLER, C ;

STROM, P ;

ROSS, SB ;

LARSSON, SA ;

FARDE, L .

PSYCHOPHARMACOLOGY, 1991, 103 (01) :6-18

[17] Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [H-3]WAY-100635 and [C-11]WAY-100635 [J].

Hall, H ;

Lundkvist, C ;

Halldin, C ;

Farde, L ;

Pike, VW ;

McCarron, JA ;

Fletcher, A ;

Cliffe, IA ;

Barf, T ;

Wikstrom, H ;

Sedvall, G .

BRAIN RESEARCH, 1997, 745 (1-2) :96-108

[18]

HALL H, 1994, DOPAMINE RECEPTORS T, P3

[19]

HALL H, 1998, UNPUB DISTRIBUTION D

[20]

Halldin C, 1996, SYNAPSE, V22, P386, DOI 10.1002/(SICI)1098-2396(199604)22:4<386::AID-SYN10>3.0.CO

← 1 2 3 4 →