Aromatic inhibitors of dehydroquinate synthase: Synthesis, evaluation and implications for gallic acid biosynthesis

被引：14

作者：

Chandran, SS

Frost, JW ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48823 USA

[2] Michigan State Univ, Dept Chem Engn, E Lansing, MI 48823 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 12期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0960-894X(01)00065-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The role of the active site metal in determining binding to 3-dehydroquinate synthase has been examined. Protocatechuic acid, catechol, and derivatives of these aromatics were synthesized that shared the common element of an ortho dihydroxylated benzene ring. Inhibition constants were determined for each aromatic as well as the variation of this inhibition as a function of whether Co+2 or Zn+2 was the active site metal ion. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1493 / 1496

页数：4

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