Watershed infarcts in a multiple microembolic model of monkey

被引：22

作者：

Maki, Takakuni ^{[1
]}

Wakita, Hideaki ^{[2
]}

Mase, Mitsuhito ^{[3
]}

Itagaki, Iori ^{[4
]}

Saito, Naoyuki ^{[4
]}

Ono, Fumiko ^{[4
]}

Adachi, Kayo ^{[2
]}

Ito, Hidefumi ^{[1
]}

Takahashi, Ryosuke ^{[1
]}

Ihara, Masafumi ^{[1
]}

Tomimoto, Hidekazu ^{[5
]}

机构：

[1] Kyoto Univ, Dept Neurol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan

[2] Natl Ctr Geriatr & Gerontol, Dept Vasc Dementia Res, Natl Inst Longev Sci, Tokyo, Japan

[3] Nagoya City Univ, Dept Neurosurg & Restorat Neurosci, Grad Sch Med Sci, Nagoya, Aichi, Japan

[4] Corp Prod & Res Lab Primates, Tsukuba, Ibaraki, Japan

[5] Mie Univ, Dept Neurol, Grad Sch Med, Tsu, Mie, Japan

来源：

NEUROSCIENCE LETTERS | 2011年 / 499卷 / 02期

关键词：

Watershed infarct; Embolic; Hemodynamic; Macaque monkey; CAROTID-ARTERY-DISEASE; STROKE; STENOSIS; MECHANISM; ISCHEMIA; EMBOLISM; MARKER; BRAIN;

D O I：

10.1016/j.neulet.2011.05.036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50 mu m microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n = 4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：80 / 83

页数：4

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