Transient decrease in cerebral motor pathway fractional anisotropy after focal ischemic stroke in monkey

被引：13

作者：

Chin, Yo ^{[1
]}

Sato, Yuki ^{[1
]}

Mase, Mitsuhito ^{[4
]}

Kato, Tomomasa ^{[1
]}

Herculano, Bruno ^{[1
]}

Sekino, Masaki ^{[2
,3
]}

Ohsaki, Hiroyuki ^{[2
,3
]}

Ageyama, Naohide ^{[5
]}

Ono, Fumiko ^{[5
]}

Terao, Keiji ^{[5
]}

Yoshikawa, Yasuhiro ^{[6
]}

Hisatsune, Tatsuhiro ^{[1
,3
]}

机构：

[1] Univ Tokyo, Dept Integrated Biosci, Chiba 2778562, Japan

[2] Univ Tokyo, Dept Adv Energy, Chiba 2778562, Japan

[3] Univ Tokyo, Grad Sch Frontier Sci, Bioimaging Ctr, Chiba 2778562, Japan

[4] Nagoya City Univ, Grad Sch Med Sci, Dept Neurosurg & Restorat Neurosci, Mizuho Ku, Nagoya, Aichi 4678602, Japan

[5] Natl Inst Biomed Innovat, Tsukuba Primate Res Ctr, Tsukuba, Ibaraki 3050843, Japan

[6] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Biomed Sci, Bunkyo Ku, Tokyo 1138657, Japan

来源：

NEUROSCIENCE RESEARCH | 2010年 / 66卷 / 04期

关键词：

Cerebral motor pathway; Diffusion MRI; Functional recovery; Ischemic injuries; Monkey; White matter; DIFFUSION TENSOR TRACTOGRAPHY; WHITE-MATTER; WALLERIAN DEGENERATION; MAGNETIC-RESONANCE; NONHUMAN-PRIMATES; MRI; RECOVERY; BRAIN; VISUALIZATION; ARCHITECTURE;

D O I：

10.1016/j.neures.2010.01.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study, diffusion tensor MRI was used to examine the restoration of the cerebral white matter of macaque monkeys after unilateral cerebral multiple microinfarctions. Post-stroke, the monkeys showed deficits in several neurological functions, including motor functions, but most of the deficits resolved within 6 weeks. Very interestingly, the fractional anisotropy (a value determined by diffusion tensor MRI), of the monkeys' affected motor pathways dropped transiently, indicating a damage in the neural tracts. However, it returned to normal levels within 6 weeks after the stroke, concomitant with the gradual recovery of motor functions at subacute phase. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：406 / 411

页数：6

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