Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochrornaffin cell 5-HT in mucosal immunity

被引：47

作者：

Yang, GB ^{[1
]}

Lackner, AA ^{[1
]}

机构：

[1] Tulane Natl Primate Res Ctr, Covington, LA 70433 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 146卷 / 1-2期

关键词：

Macaca mulatta; 5-HT; serotonin; enteroendocrine cells; mucosal immunity;

D O I：

10.1016/j.jneuroim.2003.10.044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The involvement of serotonin (5-hydroxytryptamine; 5-HT) in immunoregulation has been well documented. Gut mucosa is a large reservoir of 5-HT most of which is attributed to gut endocrine cells. In this study, we examined the anatomical relationship among 5-HT immunoreactive cells and T and B lymphocytes in the gut mucosa of rhesus monkeys (Macaca mulatta). 5-HT, CD3 and CD20 immunoreactive cells were immunofluorescently labeled and visualized by confocal microscopy. 5-HT immunoreactive cells were primarily found within the epithelium of the intestine and were present at all levels of the gastrointestinal tract. Many 5-HT immunoreactive cells were in contact with, or very close proximity to CD3(+) and CD20(+) lymphocytes. These results provide morphological evidence to suggest interactions between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa. This further supports a possible role of 5-HT in mucosal immune responses. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：46 / 49

页数：4

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