A practical, solvent free, one-pot synthesis of C2-symmetrical secondary amines

被引：43

作者：

Alexakis, A

Gille, S

Prian, F

Rosset, S

Ditrich, K

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva, Switzerland

[2] BASF Aktiengesellsch GVFEA030, D-67056 Ludwigshafen, Germany

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 07期

关键词：

reductive amination; C-2-symmetry; chiral amines; titanium isopropoxide;

D O I：

10.1016/j.tetlet.2003.12.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel one-pot reductive amination of ketones using the combination Ti((OPr)-Pr-i)(4)/H-2/Pd-C is reported. This practical procedure does not require any solvent, and affords C-2-symmetrical secondary amines in high yields and excellent diastereoselectivities. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1449 / 1451

页数：3

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