A general synthesis of structurally diverse building blocks for preparing analogues of C-linked antifreeze glycoproteins

被引：21

作者：

Eniade, A ^{[1
]}

Murphy, AV ^{[1
]}

Landreau, G ^{[1
]}

Ben, RN ^{[1
]}

机构：

[1] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA

来源：

BIOCONJUGATE CHEMISTRY | 2001年 / 12卷 / 05期

关键词：

D O I：

10.1021/bc0155059

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A synthetic methodology to afford unusual glycoconjugate building blocks useful for the solid-phase synthesis of C-linked antifreeze glycoprotein (AFGP) analogues is described. Such compounds are urgently required in order to elucidate the molecular mechanism by which AFGPs function. All reactions are general in nature and accommodate structural variation in the carbohydrate moiety, polypeptide backbone, and amino acid side chain.

引用

页码：817 / 823

页数：7

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[3]

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