Regioselective biomimetic oxidation of etodolac with iodosylbenzene catalyzed by halogenated and perhalogenated metalloporphyrins in dichloromethane

被引：10

作者：

Chauhan, SMS ^{[1
]}

Kandadai, SA ^{[1
]}

Sahoo, B ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 10期

关键词：

etodolac; halogenated and perhalogenated metalloporphyrin; iodosylbenzene; 4-hydroxyetodolac; 4-oxoetodolac;

D O I：

10.1248/cpb.49.1375

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The biomimetic oxidation of etodolac, an anti-inflammatory drug (1) with iodosylbenzene catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides TAPFe(III)CI (7a-e) in dichloromethane gives 4-hydroxyetodolac (6) and 4-oxoetodolac (5) regioselectively in moderate yields.

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收藏

页码：1375 / 1376

页数：2

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