A Ku bridge over broken DNA

被引：40

作者：

Jones, JM ^{[1
]}

Gellert, M ^{[1
]}

Yang, W ^{[1
]}

机构：

[1] NIDDKD, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

STRUCTURE | 2001年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0969-2126(01)00658-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Ku heterodimer is essential for the nonhomologous end-joining pathway of DNA double-strand break repair; it both protects the broken ends and recruits some of the many proteins required to complete repair. The recently determined structure of Ku provides insights into how it can both bind to the DNA ends and allow access by the other proteins required to rejoin them.

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收藏

页码：881 / 884

页数：4

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