De novo proteins from combinatorial libraries

被引:84
作者
Moffet, DA [1 ]
Hecht, MH [1 ]
机构
[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
关键词
D O I
10.1021/cr000051e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The technique used for analyzing De Novo proteins from combinatorial libraries were discussed. The sequences targeted to form a tetrameric α-helical bundle was solved and compared with respect to the calculated structures. The results showed that the binary code strategy for protein design produced a large collection of de Novo sequences that folded into soluble α-helical structures.
引用
收藏
页码:3191 / 3203
页数:13
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