De novo proteins from combinatorial libraries

被引：84

作者：

Moffet, DA ^{[1
]}

Hecht, MH ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 10期

关键词：

D O I：

10.1021/cr000051e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The technique used for analyzing De Novo proteins from combinatorial libraries were discussed. The sequences targeted to form a tetrameric α-helical bundle was solved and compared with respect to the calculated structures. The results showed that the binary code strategy for protein design produced a large collection of de Novo sequences that folded into soluble α-helical structures.

引用

页码：3191 / 3203

页数：13

共 102 条

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