New acylated triterpene saponins from Silene fortunei that modulate lymphocyte proliferation

被引:44
作者
Gaidi, G
Miyamoto, T
Laurens, V
Lacaille-Dubois, MA
机构
[1] Univ Bourgogne, Fac Pharm, UMIB, Lab Pharmacognosie, F-21079 Dijon, France
[2] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 812, Japan
[3] Univ Bourgogne, Fac Sci, CNRS, Grp Immunol Comparee,UMR 5548, F-21079 Dijon, France
来源
JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 11期
关键词
D O I
10.1021/np020105a
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Three new acylated triterpene saponins 1-3, with a quillaic acid as aglycon, were isolated from the roots of Silene fortunei together with a known phytoecdysteroid (20-hydroxyecdysone). The compounds were characterized mainly by a combination of 2D NMR techniques, mass spectrometry, and chemical methods. Saponins 1-3, jenisseensosides C and D (4, 5), and 6 (deacylated form of 2/3 and 4/5) were found to stimulate the proliferation of the Jurkat tumor cell lines at low concentration. At high concentration, 2/3 and 4/5 inhibited the proliferation of the cells and suggested the induction of apoptosis.
引用
收藏
页码:1568 / 1572
页数:5
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