Characterization and distribution of mechanically competent mineralized tissue in micropores of β-tricalcium phosphate bone substitutes

被引：112

作者：

Bohner, Marc ^{[1
]}

Baroud, Gamal ^{[2
]}

Bernstein, Anke ^{[3
]}

Doebelin, Nicola ^{[1
]}

Galea, Laetitia ^{[1
]}

Hesse, Bernhard ^{[4
]}

Heuberger, Roman ^{[1
]}

Meille, Sylvain ^{[5
]}

Michel, Pascal ^{[1
]}

von Rechenberg, Brigitte ^{[6
]}

Sague, Jorge ^{[1
]}

Seeherman, Howard ^{[7
]}

机构：

[1] RMS Fdn, CH-2544 Bettlach, Switzerland

[2] Univ Sherbrooke, Fac Genie, Lab Biomecan, Sherbrooke, PQ J1K 2R1, Canada

[3] Albert Ludwigs Univ, Med Ctr Freiburg, Dept Orthoped & Trauma Surg, D-79106 Freiburg, Germany

[4] European Synchrotron Radiat Facil, CS40220, F-38043 Grenoble 9, France

[5] Univ Lyon, INSA Lyon, MATEIS CNRS UMR5510, F-69621 Villeurbanne, France

[6] Univ Zurich, Musculoskeletal Res Unit MSRU, Competence Ctr Appl Biotechnol & Mol Med CABMM, Equine Hosp, CH-8057 Zurich, Switzerland

[7] BU Photon Ctr, BioVentus Surg, Boston, MA 02215 USA

来源：

MATERIALS TODAY | 2017年 / 20卷 / 03期

关键词：

IN-VIVO BEHAVIOR; CANALICULAR NETWORK MORPHOLOGY; ENGINEERING SCAFFOLDS; TRABECULAR BONE; CALCIUM; CERAMICS; OSTEOINDUCTION; BIOMATERIALS; DEFECTS; REPAIR;

D O I：

10.1016/j.mattod.2017.02.002

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Although bone formation around and within implants has been intensively studied, the role of pores and pore geometry is still debated. Notwithstanding studies reporting the formation of bone and bone components within pores as small as a few micrometers ('micropores'), bone ingrowth is believed to only occur in pores larger than 100 mu m ('macropores'). A thorough analysis of 10 different porous beta-tricalcium phosphate cylinders (empty set: 8 mm; L: 13 mm) implanted for 2-24 weeks in an ovine model demonstrates ingrowth of mineralized tissue (MT) in pores as small as 1 mu m. This tissue contained calcium phosphate, collagen, and interconnected cells. It formed within the first 3-4 weeks of implantation, extended over several hundred micrometers within the ceramic, and contributed to the majority of the early MT formation (including bone) in the defect. The indentation stiffness of the MT-ceramic composite was significantly higher than that of bone and MT-free ceramic. The presented results substantiate the importance of micropores for optimal bone healing, particularly at early implantation times.

引用

页码：106 / 115

页数：10

共 43 条

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