Molecular mechanisms controlling the development of dopaminergic neurons

被引：21

作者：

Lin, JC ^{[1
]}

Rosenthal, A ^{[1
]}

机构：

[1] Rinat Neurosci Corp, Palo Alto, CA 94304 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 03期

关键词：

dopamine; development; neuron; stem cells;

D O I：

10.1016/S1084-9521(03)00009-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dopaminergic (DA) neurons in the midbrain are critically involved in several neurological-psychiatric illnesses and are specifically lost in Parkinson's disease. The DA neurons are generated through the interactions of multiple extrinsic and intrinsic factors during the embryogenesis. The identities and mechanisms of actions of a subset of these factors have recently been elucidated. The same factors have also been successfully used to induce efficient differentiation of DA neurons in vitro from embryonic stem cells or neural progenitors. These advances have far reaching scientific and medical implications. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：175 / 180

页数：6

相关论文

共 52 条

[1] Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system [J].

Abeliovich, A ;

Schmitz, Y ;

Fariñas, I ;

Choi-Lundberg, D ;

Ho, WH ;

Castillo, PE ;

Shinsky, N ;

Verdugo, JMG ;

Armanini, M ;

Ryan, A ;

Hynes, M ;

Phillips, H ;

Sulzer, D ;

Rosenthal, A .

NEURON, 2000, 25 (01) :239-252

[2]

Adams KA, 2000, DEVELOPMENT, V127, P1857

[3] A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain [J].

Bäckman, C ;

Perlmann, T ;

Wallén, Å ;

Hoffer, BJ ;

Morales, M .

BRAIN RESEARCH, 1999, 851 (1-2) :125-132

[4] Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain [J].

Bagri, A ;

Marín, O ;

Plump, AS ;

Mak, J ;

Pleasure, SJ ;

Rubenstein, JLR ;

Tessier-Lavigne, M .

NEURON, 2002, 33 (02) :233-248

[5] Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model [J].

Björklund, LM ;

Sánchez-Pernaute, R ;

Chung, SM ;

Andersson, T ;

Chen, IYC ;

McNaught, KS ;

Brownell, AL ;

Jenkins, BG ;

Wahlestedt, C ;

Kim, KS ;

Isacson, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2344-2349

[6] A null mutation in TGF-α leads to a reduction in midbrain dopaminergic neurons in the substantia nigra [J].

Blum, H .

NATURE NEUROSCIENCE, 1998, 1 (05) :374-377

[7] Neuroprotective and neurorestorative strategies for Parkinson's disease [J].

Dawson, TM ;

Dawson, VL .

NATURE NEUROSCIENCE, 2002, 5 (Suppl 11) :1058-1061

[8]

Epstein DJ, 2000, DEVELOPMENT, V127, P4701

[9]

Epstein DJ, 1999, DEVELOPMENT, V126, P281

[10] Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons [J].

Granholm, AC ;

Reyland, M ;

Albeck, D ;

Sanders, L ;

Gerhardt, G ;

Hoernig, G ;

Shen, LY ;

Westphal, H ;

Hoffer, B .

JOURNAL OF NEUROSCIENCE, 2000, 20 (09) :3182-3190

← 1 2 3 4 5 6 →