Neuroprotective and neurorestorative strategies for Parkinson's disease

被引：142

作者：

Dawson, TM

Dawson, VL ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21287 USA

来源：

NATURE NEUROSCIENCE | 2002年 / 5卷 / Suppl 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nn941

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Advances in understanding the molecular mechanisms of cell death and the pathogenesis of sporadic and familial Parkinson's disease are creating new opportunities for the development of neuroprotective and/or neurorestorative therapies. Here we review many of these advances, highlighting areas and strategies that might be particularly suited to the development of innovative approaches that prevent degeneration and/or restore function in Parkinson's disease.

引用

页码：1058 / 1061

页数：4

共 35 条

[1] Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
Auluck, PK
Chan, HYE
Trojanowski, JQ
Lee, VMY
Bonini, NM
[J]. SCIENCE, 2002, 295 (5556) : 865 - 868
[2] Experimental models of Parkinson's disease
Beal, MF
[J]. NATURE REVIEWS NEUROSCIENCE, 2001, 2 (05) : 325 - 332
[3] Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R
Sherer, TB
MacKenzie, G
Garcia-Osuna, M
Panov, AV
Greenamyre, JT
[J]. NATURE NEUROSCIENCE, 2000, 3 (12) : 1301 - 1306
[4] Parkinson disease gene therapy moves toward the clinic
Björklund, A
Lindvall, O
[J]. NATURE MEDICINE, 2000, 6 (11) : 1207 - 1208
[5] Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
Björklund, LM
Sánchez-Pernaute, R
Chung, SM
Andersson, T
Chen, IYC
McNaught, KS
Brownell, AL
Jenkins, BG
Wahlestedt, C
Kim, KS
Isacson, O
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) : 2344 - 2349
[6] The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders
Chung, KKK
Dawson, VL
Dawson, TM
[J]. TRENDS IN NEUROSCIENCES, 2001, 24 (11) : S7 - S14
[7] Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
Conway, KA
Rochet, JC
Bieganski, RM
Lansbury, PT
[J]. SCIENCE, 2001, 294 (5545) : 1346 - 1349
[8] Date I, 2001, CELL TRANSPLANT, V10, P397
[9] Animal models of PD: Pieces of the same puzzle?
Dawson, TM
Mandir, AS
Lee, MK
[J]. NEURON, 2002, 35 (02) : 219 - 222
[10] Prospects for new restorative and neuroprotective treatments in Parkinson's disease
Dunnett, SB
Björklund, A
[J]. NATURE, 1999, 399 (6738) : A32 - A39

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