The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers

被引：39

作者：

Pretze, Marc ^{[1
]}

Wuest, Frank ^{[2
]}

Peppel, Tim ^{[3
]}

Koeckerling, Martin ^{[3
]}

Mamat, Constantin ^{[1
]}

机构：

[1] Res Ctr Dresden Rossendorf, Inst Radiopharm, POB 51 01 19, D-01314 Dresden, Germany

[2] Univ Alberta, Cross Canc Inst, Dept Oncol Imaging, Edmonton, AB T6G 1Z2, Canada

[3] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 49期

关键词：

Radiolabeling; Traceless Staudinger ligation; Bioorthogonal; Fluorine-18; CLICK-CHEMISTRY; PHOSPHANE-BORANES;

D O I：

10.1016/j.tetlet.2010.09.134

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

The development of rapid radiolabeling techniques under mild reaction conditions involving the short-lived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6410 / 6414

页数：5

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