Reversion of 'early worsening' of diabetic retinopathy by deliberate restoration of poor metabolic control

被引：25

作者：

Chantelau, E

Meyer-Schwickerath, R

机构：

[1] Univ Dusseldorf, Diabet Ambulanz MNR Klin, DE-40001 Dusseldorf, Germany

[2] Ophthalmol Practice, Bocholt, Germany

来源：

OPHTHALMOLOGICA | 2003年 / 217卷 / 05期

关键词：

proliferative retinopathy; vitrectomy; diabetes complications; intensive insulin therapy; adverse effects; haemoglobin A(1c); vascular endothelial growth factor; macular oedema; VEGF;

D O I：

10.1159/000071355

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Acutely lowering long-standing severe hyperglycaemia can trigger progression ('early worsening') of diabetic retinopathy, most likely by up-regulation of the circulating insulin-like growth factor 1 (IGF-1). This condition, also called 'florid retinopathy', rarely responds to standard laser coagulation treatment. In this retrospective report, 2 young patients with type 2 diabetes are described, in whom deliberate restoration of poor diabetes control reduced the serum IGF-1 levels and improved 'early worsened' diabetic retinopathy. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：373 / 377

页数：5

共 23 条

[21] Defining the relationship between plasma glucose and HbA1c -: Analysis of glucose profiles and HbA1c in the Diabetes Control and Complications Trial [J].