Betulinic Acid, a Natural Pentacyclic Triterpenoid, Prevents Abdominal Fat Accumulation in Mice Fed a High-Fat Diet

被引：108

作者：

de Melo, Celio L. ^{[2
]}

Queiroz, Maria Goretti R. ^{[2
]}

Arruda Filho, Antonio Carlos V. ^{[2
]}

Rodrigues, Adriana M. ^{[2
]}

de Sousa, Daniel F. ^{[2
]}

Almeida, Jose Gustavo L. ^{[3
]}

Pessoa, Otilia Deusdenia L. ^{[3
]}

Silveira, Edilberto R. ^{[3
]}

Menezes, Dalgimar B. ^{[4
]}

Melo, Tiago S.

Santos, Flavia A.

Rao, Vietla S. ^{[1
]}

机构：

[1] Univ Fed Ceara, Fac Med, Dept Physiol & Pharmacol, BR-60430270 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Clin & Toxicol Anal, BR-60430270 Fortaleza, Ceara, Brazil

[3] Univ Fed Ceara, Dept Organ & Inorgan Chem, BR-60430270 Fortaleza, Ceara, Brazil

[4] Univ Fed Ceara, Dept Pathol, BR-60430270 Fortaleza, Ceara, Brazil

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2009年 / 57卷 / 19期

关键词：

Betulinic acid; pentacyclic triterpene; high-fat diet; antiobesity effect; hypoglycemic effect; INHIBITORY-ACTIVITY; INDUCED OBESITY; ANTHOCYANINS; SAPONINS; GHRELIN; LEPTIN; LEAVES;

D O I：

10.1021/jf900768w

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

In the search for potential antiobese agents from natural sources, this study investigated the effects of betulinic acid (BA), a pentacyclic triterpene from Clusia nemorosa L. (Clusiaceae), in mice on a high-fat diet (HFD). Adult male Swiss mice (n = 8) treated or not with BA (50 mg/L, in drinking water) were fed a HFD during 15 weeks. Mice treated with BA and fed a HFD showed significantly (P < 0.05) decreased body weights, abdominal fat accumulation, blood glucose, plasma triglycerides, and total cholesterol relative to their respective controls fed no BA. Additionally, BA treatment, while significantly elevating the plasma hormone levels of insulin and leptin, decreased the level of ghrelin. However, it caused a greater decrease in plasma amylase activity than the lipase. These findings suggest that BA has an antiobese potential through modulation of fat and carbohydrate metabolism,and it may be a suitable lead compound in the treatment of obesity.

引用

页码：8776 / 8781

页数：6

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