Crystallization in polymorphic systems:: The solution-mediated transformation β to α glycine

被引：144

作者：

Ferrari, ES ^{[1
]}

Davey, RJ ^{[1
]}

Cross, WI ^{[1
]}

Gillon, AL ^{[1
]}

Towler, CS ^{[1
]}

机构：

[1] UMIST, Dept Chem Engn, Crystals Colloids & Interfaces Grp, Manchester M60 1QD, Lancs, England

来源：

CRYSTAL GROWTH & DESIGN | 2003年 / 3卷 / 01期

关键词：

D O I：

10.1021/cg025561b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The crystallization and subsequent polymorphic transformation from the beta to the alpha form of glycine has been studied using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy techniques. The crystal structure and morphology of beta glycine have been determined, and the influence of solvent, solubility, and process scale on its solvent-mediated transformation to the alpha form was quantified. It is concluded that for the low solubility environments used in this study, the rate-determining step in the transformation process is the dissolution rate of the metastable beta polymorph.

引用

页码：53 / 60

页数：8

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