Drug Interactions of Clinical Importance among the Opioids, Methadone and Buprenorphine, and Other Frequently Prescribed Medications: A Review

被引：221

作者：

McCance-Katz, Elinore F. ^{[1
]}

Sullivan, Lynn E. ^{[2
]}

Nallani, Srikanth ^{[3
]}

机构：

[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[2] Yale Univ, Dept Internal Med, New Haven, CT USA

[3] US FDA, Off Clin Pharmacol, CDER, Silver Spring, MD USA

来源：

AMERICAN JOURNAL ON ADDICTIONS | 2010年 / 19卷 / 01期

关键词：

HEPATITIS-C VIRUS; CYTOCHROME-P450; 3A4; OPIATE WITHDRAWAL; N-DEMETHYLATION; HIV; PHARMACOKINETICS; INVOLVEMENT; ZIDOVUDINE; CYP3A; ANTIRETROVIRALS;

D O I：

10.1111/j.1521-0391.2009.00005.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co-occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid-addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. This review summarizes current literature in this area. (Am J Addict 2009;19:4-16).

引用

页码：4 / 16

页数：13

共 92 条

[31] Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes [J].

Iribarne, C ;

Berthou, F ;

Baird, S ;

Dreano, Y ;

Picart, D ;

Bail, JP ;

Beaune, P ;

Menez, JF .

CHEMICAL RESEARCH IN TOXICOLOGY, 1996, 9 (02) :365-373

[32] Involvement of cytochrome P450 3A4 in N-dealkylation of buprenorphine in human liver microsomes [J].

Iribarne, C ;

Picart, D ;

Dreano, Y ;

Bail, JP ;

Berthou, F .

LIFE SCIENCES, 1997, 60 (22) :1953-1964

[33]

IRIBARNE C, 1998, FUND CLIN PHARM, V2, P94

[34]

KARAN L, 2008, PRINCIPLES ADDICTION, P67

[35]

KARIN H, 2000, LANCET, V356, P2069

[36] Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity [J].

Kharasch, Evan D. ;

Walker, Alysa ;

Whittington, Dale ;

Hoffer, Christine ;

Bedynek, Pamela Sheffels .

DRUG AND ALCOHOL DEPENDENCE, 2009, 101 (03) :158-168

[37] Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport Insights from Methadone Interactions with Ritonavir/Indinavir [J].

Kharasch, Evan D. ;

Hoffer, Christine ;

Whittington, Dale ;

Walker, Alysa ;

Bedynek, Pamela Sheffels .

ANESTHESIOLOGY, 2009, 110 (03) :660-672

[38] Pharmacologic treatments for heroin and cocaine dependence [J].

Kleber, HD .

AMERICAN JOURNAL ON ADDICTIONS, 2003, 12 :S5-S18

[39]

KOSTEN TR, 1986, ARCH GEN PSYCHIAT, V43, P733

[40] Dose-related effects of methadone on QT prolongation in a series of patients with Torsade de Pointes [J].

Krantz, MJ ;

Kutinsky, IB ;

Robertson, AD ;

Mehler, PS .

PHARMACOTHERAPY, 2003, 23 (06) :802-805

← 1 2 3 4 5 6 7 8 9 10 →