Nuclei Take a Position: Managing Nuclear Location

被引：119

作者：

Burke, Brian ^{[1
,2
]}

Roux, Kyle J. ^{[1
]}

机构：

[1] Univ Florida, Dept Anat & Cell Biol, Gainesville, FL 32610 USA

[2] Inst Med Biol, Singapore 138648, Singapore

来源：

DEVELOPMENTAL CELL | 2009年 / 17卷 / 05期

关键词：

KASH-DOMAIN PROTEINS; CYTOPLASMIC DYNEIN; MEMBRANE PROTEIN; LAMIN-A; ENVELOPE BREAKDOWN; MIGRATION; CENTROSOME; CELLS; ACTIN; LOCALIZATION;

D O I：

10.1016/j.devcel.2009.10.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic cells display considerable morphological plasticity linked to their abilities to carry out a myriad of complex functions. Structural rearrangements associated with cellular activities, from yeast mitosis to cell migration in the mammalian central nervous system, often involve relocation of the cell nucleus. Recent studies have provided insight into how nuclear components can be mechanically coupled to the cytoskeleton, providing a more complete understanding of the role of nuclear positioning in both health and disease.

引用

页码：587 / 597

页数：11

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