Polymeric Ig receptor: Defender of the fort or Trojan Horse?

被引：47

作者：

Kaetzel, CS ^{[1
]}

机构：

[1] Univ Kentucky, Med Ctr, Dept Pathol, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Microbiol Immunol, Lexington, KY 40536 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0960-9822(00)00041-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The polymeric immunoglobulin receptor (plgR) is important in host defense, transporting antibodies across mucosal epithelial cells. Recent work has shown that, using a protein that binds directly to the plgR, Streptococcus pneomoniae can co-opt the transcytosis machinery and gain entry into airway epithelial cells.

引用

页码：R35 / R38

页数：4

共 20 条

[1] The B-cell system of human mucosae and exocrine glands [J].

Brandtzaeg, P ;

Farstad, IN ;

Johansen, FE ;

Morton, HC ;

Norderhaug, IN ;

Yamanaka, T .

IMMUNOLOGICAL REVIEWS, 1999, 171 :45-87

[2] ALTERNATE SPLICING OF RABBIT POLYMERIC IMMUNOGLOBULIN RECEPTOR [J].

DEITCHER, DL ;

MOSTOV, KE .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (07) :2712-2715

[3]

DEVELASCO EA, 1995, MICROBIOL REV, V59, P591

[4] Epithelial cell polarization is a determinant in the infectious outcome of immunoglobulin a-mediated entry by Epstein-Barr virus [J].

Gan, YJ ;

Chodosh, J ;

Morgan, A ;

Sixbey, JW .

JOURNAL OF VIROLOGY, 1997, 71 (01) :519-526

[5] SpsA, a novel pneumococcal surface protein with specific binding to secretory Immunoglobulin A and secretory component [J].

Hammerschmidt, S ;

Talay, SR ;

Brandtzaeg, P ;

Chhatwal, GS .

MOLECULAR MICROBIOLOGY, 1997, 25 (06) :1113-1124

[6] Species-specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif [J].

Hammerschmidt, S ;

Tillig, MP ;

Wolff, S ;

Vaerman, JP ;

Chhatwal, GS .

MOLECULAR MICROBIOLOGY, 2000, 36 (03) :726-736

[7] Decreased vaginal disease in J-chain-deficient mice following herpes simplex type 2 genital infection [J].

Hendrickson, BA ;

Guo, J ;

Brown, I ;

Dennis, K ;

Marcellino, D ;

Hetzel, J ;

Herold, BC .

VIROLOGY, 2000, 271 (01) :155-162

[8] Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor [J].

Hughes, GJ ;

Frutiger, S ;

Savoy, LA ;

Reason, AJ ;

Morris, HR ;

Jaton, JC .

FEBS LETTERS, 1997, 410 (2-3) :443-446

[9] Interaction of antigens and antibodies at mucosal surfaces [J].

Lamm, ME .

ANNUAL REVIEW OF MICROBIOLOGY, 1997, 51 :311-340

[10]

Lin CT, 1997, AM J PATHOL, V150, P1745

← 1 2 →