Can measurement of B-type natriuretic peptide levels improve cardiovascular disease prevention?

被引：17

作者：

Campbell, Duncan J. ^{[1
,2
]}

机构：

[1] St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia

[2] Univ Melbourne, St Vincents Hosp, Dept Med, Fitzroy, Vic 3065, Australia

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2008年 / 35卷 / 04期

关键词：

amino-terminal pro-BNP (NT-proBNP); atrial fibrillation; B-type natriuretic peptide (BNP); cardiovascular disease; heart failure; myocardial infarction; risk factor; stroke;

D O I：

10.1111/j.1440-1681.2008.04894.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The measurement of plasma levels of B-type natriuretic peptide (BNP) and amino-terminal pro-BNP (NT-proBNP) provides useful diagnostic information in patients with suspected heart failure and valuable prognostic information in patients with heart failure, acute coronary syndrome, valvular heart disease and other cardiac pathologies. 2. BNP- and NT-proBNP-guided heart failure therapy improves patient outcomes. 3. An increasing number of studies shows plasma BNP and NT-proBNP levels predict all-cause mortality and cardiovascular events including heart failure, myocardial infarction, stroke, atrial fibrillation and cardiovascular death in stable patients with or without known cardiovascular disease and provide information about cardiovascular risk additional to that provided by traditional risk factors. 4. Anti hypertensive therapy reduces elevated NT-proBNP levels in individuals at increased cardiovascular risk, thereby suggesting that change in NT-proBNP levels provides a measure of risk reduction. 5. Thus, monitoring of BNP and NT-proBNP levels offers the possibilities of improved targeting of individuals with increased cardiovascular risk and optimization of strategies for primary and secondary prevention of cardiovascular disease. 6. There is need for an outcome study to determine whether BNP- or NT-proBNP-guided therapy improves cardiovascular disease prevention.

引用

页码：442 / 446

页数：5

共 59 条

[51] Explaining the decline in coronary heart disease mortality in England and Wales between 1981 and 2000 [J].

Unal, B ;

Critchley, JA ;

Capewell, S .

CIRCULATION, 2004, 109 (09) :1101-1107

[52] A strategy to reduce cardiovascular disease by more than 80% [J].

Wald, NJ ;

Law, MR .

BMJ-BRITISH MEDICAL JOURNAL, 2003, 326 (7404) :1419-1423

[53] Brain natriuretic peptide predicts mortality in the elderly [J].

Wallen, T ;

Landahl, S ;

Hedner, T ;

Nakao, K ;

Saito, Y .

HEART, 1997, 77 (03) :264-267

[54] Multiple biomarkers for the prediction of first major cardiovascular events and death [J].

Wang, Thomas J. ;

Gona, Philimon ;

Larson, Martin G. ;

Tofler, Geoffrey H. ;

Levy, Daniel ;

Newton-Cheh, Christopher ;

Jacques, Paul F. ;

Rifai, Nader ;

Selhub, Jacob ;

Robins, Sander J. ;

Benjamin, Emelia J. ;

D'Agostino, Ralph B. ;

Vasan, Ramachandran S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (25) :2631-2639

[55] Impact of obesity on plasma natriuretic peptide levels [J].

Wang, TJ ;

Larson, MG ;

Levy, D ;

Benjamin, EJ ;

Leip, EP ;

Wilson, PWF ;

Vasan, RS .

CIRCULATION, 2004, 109 (05) :594-600

[56] Plasma natriuretic peptide levels and the risk of cardiovascular events and death [J].

Wang, TJ ;

Larson, MG ;

Levy, D ;

Benjamin, EJ ;

Leip, EP ;

Omland, T ;

Wolf, PA ;

Vasan, RS .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (07) :655-663

[57] Statistics and medicine - The limitations of risk factors as prognostic tools [J].

Ware, James H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (25) :2615-2617

[58] Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes - Principal results of the Conduit Artery Function Evaluation (CAFE) study [J].

Williams, B ;

Lacy, PS ;

Thom, SM ;

Cruickshank, K ;

Stanton, A ;

Collier, D ;

Hughes, AD ;

Thurston, H .

CIRCULATION, 2006, 113 (09) :1213-1225

[59] Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study [J].

Yusuf, S ;

Hawken, S ;

Ounpuu, S ;

Dans, T ;

Avezum, A ;

Lanas, F ;

McQueen, M ;

Budaj, A ;

Pais, P ;

Varigos, J ;

Liu, LS .

LANCET, 2004, 364 (9438) :937-952

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