Vaccines for the Elderly

被引：24

作者：

Del Giudice, Giuseppe ^{[1
]}

Weinberger, Birgit ^{[2
]}

Grubeck-Loebenstein, Beatrix ^{[1
]}

机构：

[1] Novartis Vaccines, Res Ctr, IT-53100 Siena, Italy

[2] Univ Innsbruck, Inst Biomed Aging Res, A-6020 Innsbruck, Austria

来源：

GERONTOLOGY | 2015年 / 61卷 / 03期

关键词：

Elderly; Immune system; Immunosenescence; Vaccine technology; RESPIRATORY SYNCYTIAL VIRUS; INFLUENZA VACCINATION; ANTIBODY-RESPONSE; IMMUNE-RESPONSES; HERPES-ZOSTER; ADJUVANT; ADULTS; INFECTION; IMMUNOSENESCENCE; POLYSACCHARIDE;

D O I：

10.1159/000366162

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The aging of the human population is posing serious challenges to research and to public health authorities in order to prevent diseases that more frequently affect the elderly, a portion of the population that will increase more and more in the coming years. While some vaccines exist and are used in the elderly to effectively fight against some infections (e.g. influenza, pneumococci, varicella-zoster virus, diphtheria, and tetanus), still a lot of work remains to be done to better adapt these vaccines and to develop new ones for this age group. The prevention of infectious diseases affecting the elderly can be successful only through a holistic approach. This approach will aim at the following: (1) a deeper understanding of the mechanisms leading to the senescence of the immune system, (2) a better and broader use of vaccines recommended for the elderly, (3) the use of vaccines currently considered only for other age groups and (4) actively priming the population when they are immunological competent, before the physiological waning of immune responsiveness may affect the beneficial effects of vaccination. (C) 2014 S. Karger AG, Basel

引用

页码：203 / 210

页数：8

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