A New Method for Aromatic Difluoromethylation: Copper-Catalyzed Cross-Coupling and Decarboxylation Sequence from Aryl Iodides

被引：283

作者：

Fujikawa, Kenichi ^{[1
]}

Fujioka, Yasutaka ^{[1
]}

Kobayashi, Akira ^{[2
]}

Amii, Hideki ^{[1
,2
]}

机构：

[1] Kobe Univ, Grad Sch Sci, Dept Chem, Kobe, Hyogo 6578501, Japan

[2] Gunma Univ, Dept Chem & Chem Biol, Grad Sch Engn, Gunma 3768515, Japan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 20期

关键词：

MEDIATED FLUOROALKYLATION REACTIONS; OXIDATIVE TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; BOND-FORMATION; PALLADIUM; ACIDS; BROMODIFLUOROACETATE; FLUORINATION; REACTIVITY; INHIBITORS;

D O I：

10.1021/ol202289z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with alpha-silyldifluoroacetates upon treatment with copper catalyst in DMSO or DME to give the corresponding aryldifluoroacetates in moderate to good yields. The subsequent hydrolysis of aryldifluoroacetates and KF-promoted decarboxylation afforded a variety of difluoromethyl aromatics.

引用

页码：5560 / 5563

页数：4

共 74 条

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