RNA polymerase III under control: repression and de-repression

被引：27

作者：

Boguta, Magdalena ^{[1
,2
]}

Graczyk, Damian ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland

[2] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2011年 / 36卷 / 09期

关键词：

PROTEIN-KINASE CK2; TATA-BINDING PROTEIN; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION REPRESSION; GENE-TRANSCRIPTION; HUMAN-CELLS; DNA-DAMAGE; MAF1; PHOSPHORYLATION; MACHINERY;

D O I：

10.1016/j.tibs.2011.06.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of tRNA by yeast RNA polymerase III (Pol III) is regulated in response to changing environmental conditions. This control is mediated by Maf1, the global negative regulator of Pol III transcription conserved from yeast to humans. Details regarding the molecular basis of Pot III repression by Maf1 are now emerging from recently reported structural and biochemical data on Pot III and Maf1. Efficient Pol III transcription, following the shift of cells from a non-fermentable carbon source to glucose, requires phosphorylation of Maf1. One of the newly identified Maf1 kinases is the chromatin-bound casein kinase II (CK2). Current studies have allowed us to propose an innovative mechanism of Pol III regulation. We suggest that CK2-mediated phosphorylation of Maf1, occurring directly on tDNA chromatin, controls Pot III recycling.

引用

页码：451 / 456

页数：6

共 49 条

[1] Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I [J].