Progression through the RNA Polymerase II CTD Cycle

被引：567

作者：

Buratowski, Stephen ^{[1
]}

机构：

[1] Harvard Univ, Dept Biol Chem & Mol Pharmacol, Sch Med, Boston, MA 02115 USA

来源：

MOLECULAR CELL | 2009年 / 36卷 / 04期

关键词：

CARBOXY-TERMINAL DOMAIN; PROMOTES TRANSCRIPTION TERMINATION; PROCESSING FACTORS; KINASE; PHOSPHORYLATION; RECRUITMENT; ELONGATION; SNRNA; PHOSPHATASE; INTERACTS;

D O I：

10.1016/j.molcel.2009.10.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The C-terminal domain of RNA polymerase H's largest subunit undergoes dynamic phosphorylation during transcription, and the different phosphorylation patterns that predominate at each stage of transcription recruit the appropriate set of mRNA-processing and histone-modifying factors. Recent papers help to explain how the changes in CTD phosphorylation pattern are linked to the progression from initiation through elongation to termination.

引用

页码：541 / 546

页数：6

共 48 条

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