Prednisone and plasma exchange improve suppressor cell function in chronic inflammatory demyelinating polyneuropathy

被引：32

作者：

De Luca, G

Lugaresi, A

Iarlori, C

Marzoli, F

Di Iorio, A

Gambi, D

Uncini, A

机构：

[1] Univ Chieti, Policlin Clinicizzato Colle Dell Ara, Ctr Neuromuscular Dis, Dept Oncol & Neurosci, I-66013 Chieti, Italy

[2] Policlin Clinicizzato Colle Dell Ara, Dept Med & Aging, I-66013 Chieti, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1999年 / 95卷 / 1-2期

关键词：

chronic inflammatory demyelinating polyneuropathy; ConA; cytokines; plasma exchange; prednisone; suppressor cell function; therapy;

D O I：

10.1016/S0165-5728(98)00266-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have recently demonstrated that ConA-induced suppressor cell function is defective in chronic inflammatory demyelinating polyneuropathy (CIDP). To assess whether this defect plays a role in disease activity and its reversal is important in recovery, we studied modifications of ConA-induced suppressor cell function induced by prednisone and plasma exchange in 20 patients with CIDP. We found a significant increase towards normal of ConA-induced suppressor cell function after treatment in concurrence with clinical improvement. Induction of suppression, presumably through favorable modifications of the cytokine network or other humoral mediators, might be one, among others, of the mechanisms through which prednisone and plasma, exchange are effective in CIDP, (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：190 / 194

页数：5

共 29 条

[1]

ANTEL J, 1986, J IMMUNOL, V137, P3436

[2]

ANTEL JP, 1978, ANN NEUROL, V6, P469

[3]

ARYA SK, 1984, J IMMUNOL, V133, P273

[4]

BAHRON RJ, 1989, ARCH NEUROL-CHICAGO, V46, P878

[5]

Barnett MH, 1998, MUSCLE NERVE, V21, P454, DOI 10.1002/(SICI)1097-4598(199804)21:4<454::AID-MUS3>3.0.CO

[6]

2-8

[7]

Blotta MH, 1997, J IMMUNOL, V158, P5589

[8]

CORNBLATH DR, 1991, NEUROLOGY, V41, P617

[9] Interferon beta normalizes suppressor cell function in dysimmune neuropathies [J].

De Luca, G ;

Lugaresi, A ;

Iarlori, C ;

Marzoli, F ;

Uncini, A ;

Gambi, D .

JOURNAL OF NEUROIMMUNOLOGY, 1998, 82 (01) :1-4

[10] PREDNISONE IMPROVES CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY MORE THAN NO TREATMENT [J].

DYCK, PJ ;

OBRIEN, PC ;

OVIATT, KF ;

DINAPOLI, RP ;

DAUBE, JR ;

BARTLESON, JD ;

MOKRI, B ;

SWIFT, T ;

LOW, PA ;

WINDEBANK, AJ .

ANNALS OF NEUROLOGY, 1982, 11 (02) :136-141

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