Anti-Mullerian hormone and its receptors

被引：203

作者：

Josso, N ^{[1
]}

di Clemente, N ^{[1
]}

Gouédard, L ^{[1
]}

机构：

[1] Ecole Normale Super, INSERM, Unite Rech Endocrinol Dev, Dept Biol, F-92120 Montrouge, France

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2001年 / 179卷 / 1-2期

关键词：

anti-Mullerian hormone; Mullerian inhibiting substance; receptor; sex differentiation; signal transduction;

D O I：

10.1016/S0303-7207(01)00467-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Anti-Mullerian hormone (AMH). a member of the transforming growth facror-beta family, is an important factor of male sex differentiation. It is produced by Sertoli cells from the time of fetal sex differentiation to puberty. AMH is also produced by granulosa cells from the time of birth to the end of ovarian activity. As other members of the transforming growth factor-p family, AMH signals through two related but distinct receptors. both serine/threonine kinases with a single transmembrane domain, called type II and type I. The type II receptor has been cloned in 1994 and is expressed solely in AMH target organs. Engagement of the type I receptor BMPR-1B and downstream effector Smadl by AMH has recently been demonstrated, however, its role in AMH biological actions remains to be proven. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：25 / 32

页数：8

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