Efficient site specific cleavage of RNA using a terpyridine-copper(II) complex joined to a 2′-O-methyloligonucleotide by a non-flexible linker

被引：30

作者：

Inoue, H ^{[1
]}

Furukawa, T ^{[1
]}

Shimizu, R ^{[1
]}

Tamura, T ^{[1
]}

Matsui, MN ^{[1
]}

Ohtsuka, E ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 01期

关键词：

D O I：

10.1039/a808522f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A terpyridine-Cu(II) complex conjugated to an antisense 2'-O-methyloligonucleotide at the 5'-end cleaved RNA predominantly at the site opposite the 5'-end in moderate yield, but the cleavage yield increased by more than two-fold when a 2'-O-methyloligonucleotide was allowed to bind to the single-stranded region of the RNA-antisense complex.

引用

页码：45 / 46

页数：2

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