Interleukin-6-induced reciprocal expression of SERCA and natriuretic peptides mRNA in cultured rat ventricular myocytes

被引：90

作者：

Tanaka, T ^{[1
]}

Kanda, T ^{[1
]}

Takahashi, T ^{[1
]}

Saegusa, S ^{[1
]}

Moriya, J ^{[1
]}

Kurabayashi, M ^{[1
]}

机构：

[1] Kanazawa Med Univ, Dept Gen Med, Uchinada, Ishikawa 9200293, Japan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2004年 / 32卷 / 01期

关键词：

sarco-endoplasmic reticulum Ca(2+-)ATPase (SERCA); atrial natriuretic peptide; B-type natriuretic peptide; interleukin-6 (IL-6); ventricular myocytes;

D O I：

10.1177/147323000403200109

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We investigated the effect of interleukin-6 (IL-6) expression on sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) mRNA levels in cultured rat neonatal ventricular myocytes. IL-6 plays a key role in regulating cardiac hypertrophy and the development of heart failure, and SERCA, ANP and BNP are all cardiac hormones with regulatory properties. Compared with baseline measurements, treatment with 50 U/ml IL-6 significantly decreased SERCA gene expression, but significantly increased ANP and BNP gene expression in the cardiac myocytes. These results suggest that the clinical overproduction of IL-6 in response to infection, autoimmune disease and cancer might be responsible for cardiac hypertrophy. Cardiac hypertrophy may result from the imbalance of both natriuretic peptides and SERCA transcription levels, caused by elevated IL-6 expression.

引用

页码：57 / 61

页数：5

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