Myelodysplastic syndromes: the complexity of stem-cell diseases

被引：251

作者：

Corey, Seth J.

Minden, Mark D.

Barber, Dwayne L.

Kantarjian, Hagop

Wang, Jean C. Y.

Schimmer, Aaron D.

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Div Pediat, Houston, TX 77030 USA

[3] Princess Margaret Hosp, Div Hematol & Oncol, Toronto, ON M4X 1K9, Canada

[4] Ontario Canc Inst, Toronto, ON M4X 1K9, Canada

[5] Ontario Canc Inst, Div Stem Cell & Dev Biol, Toronto, ON M4X 1K9, Canada

[6] Ontario Canc Inst, Div Cell & Mol Biol, Toronto, ON M4X 1K9, Canada

[7] Ontario Canc Inst, Div Genom & Proteom, Toronto, ON M4X 1K9, Canada

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 02期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

D O I：

10.1038/nrc2047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prevalence of patients with myelodysplastic syndromes (MDS) is increasing owing to an ageing population and increased awareness of these diseases. MDS represent many different conditions, not just a single disease, that are grouped together by several clinical characteristics. A striking feature of MDS is genetic instability, and a large proportion of cases result in acute myeloid leukaemia (AML). We Review three emerging principles of MDS biology: stem-cell dysfunction and the overlap with AML, genetic instability and the deregulation of apoptosis, in the context of inherited bone marrow-failure syndromes, and treatment-related MDS and AML.

引用

页码：118 / 129

页数：12

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