Genetic profile identification in clinically localized prostate carcinoma

被引：9

作者：

Gallucci, Michele ^{[2
]}

Merola, Roberta ^{[1
]}

Leonardo, Costantino ^{[2
]}

De Carli, Piero ^{[2
]}

Farsetti, Antonella ^{[3
]}

Sentinelli, Steno ^{[4
]}

Sperduti, Isabella ^{[5
]}

Mottolese, Marcella ^{[4
]}

Carlini, Paolo ^{[6
]}

Vico, Erika ^{[1
]}

Simone, Giuseppe ^{[2
]}

Cianciulli, AnnaMaria ^{[1
]}

机构：

[1] Regina Elena Inst Canc Res, Dept Clin Pathol, Cytogenet Unit, Rome, Italy

[2] Regina Elena Inst Canc Res, Dept Urol, Rome, Italy

[3] CNR, Inst Neurobiol & Mol Med, Rome, Italy

[4] Regina Elena Inst Canc Res, Dept Pathol, Rome, Italy

[5] Regina Elena Inst Canc Res, Biostat Unit, Rome, Italy

[6] Regina Elena Inst Canc Res, Dept Oncol, Rome, Italy

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2009年 / 27卷 / 05期

关键词：

Prostate cancer; Cancer genetics; Chromosomal abnormalities; Prognostic studies; IN-SITU HYBRIDIZATION; RADICAL PROSTATECTOMY; CANCER PROGRESSION; ANDROGEN RECEPTOR; GLEASON SCORE-7; EXPRESSION; CHROMOSOME-7; ASSOCIATION; RECURRENCE; DELETION;

D O I：

10.1016/j.urolonc.2008.04.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To confirm our previously obtained results, we genetically characterized prostate cancer from patients undergo radical prostatectomy in a retrospective study. Materials and methods: Histological sections were evaluated for 106 patients treated with surgery from 1991 to 2004. With fluorescence in situ hybridization (FISH) method, the status of LPL (8p22), c-MYC (8q24) genes and 7, 8, X chromosomes was evaluated. Results: Chromosomes 7, 8, X aneusomy was demonstrated in 91.5%, 78.3%, and 51.9% of the samples, respectively, whereas LPL deletion and MYC amplification were found in 76.0% and 1.6%. A genetic profile was considered as unfavorable when at least two aneusomic chromosomes and one altered gene were present. Tumors with an adverse genetic profile were more frequently present in patients with higher stages (P = 0.02), biochemical/clinical progression (P = 0.03), and Gleason grade 4 + 3 (P = 0.02). Multiple correspondence analysis identified one tumor group characterized by chromosome 8 aneusomy, X polysomy, LPL gene deletion, Gleason > 7 and 4 + 3 associated with progression. Conclusions: In this study, we recognized the predictive power of previously identified cytogenetic profiles. Assessment of genetic set may characterize each patient and have influence on postoperative therapeutic strategies. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：502 / 508

页数：7

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