Potential roles of myosin VI in cell motility

被引：29

作者：

Chibalina, Margarita V. ^{[1
]}

Puri, Claudia ^{[1
]}

Kendrick-Jones, John ^{[2
]}

Buss, Folma ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 0XY, England

[2] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

actin; cancer dissemination; cell motility; membrane protrusion; myosin VI; DROSOPHILA SPERMATID INDIVIDUALIZATION; UNCONVENTIONAL MYOSIN; MEDIATED ENDOCYTOSIS; OVARIAN-CANCER; GOLGI-COMPLEX; ACTIN; MIGRATION; MORPHOGENESIS; FIBROBLASTS; TRANSPORT;

D O I：

10.1042/BST0370966

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is now increasing evidence that myosin motor proteins, together with the dynamic actin filament machinery and associated adhesion proteins, play crucial roles in the events leading to motility at the leading edge of migrating cells. Myosins exist as a large superfamily of diverse ATP-dependent motors, and in the present review, we focus on the unique minus-end-directed myosin VI, briefly discussing its potential functions in cell motility.

引用

页码：966 / 970

页数：5

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